PrintyMed is a revolutionary medicine company that focuses on the development of artificial spider silk for different medical applications. Despite the well-known applications of artificial spider silk, our team of scientists, engineers and medical professionals are working together to create material that can be used to create 3D printed living tissue. This unique approach to medicine has the potential to revolutionize the medical field and improve the lives of millions of people. We are excited to be at the forefront of this new technology and are constantly pushing the boundaries of what is possible.
About Us
Innovative high-performance biotech material
PrintyMed has developed an innovative high-performance biotech material - artificial spider silk, that is environmentally friendly, fully recycled, 100% biodegradable, biocompatible and extremely versatile thanks to its extraordinary mechanical and biochemical properties.
Enhancing biocompatibility of organ transplants and medical devices
The PrintyMed artificial spider silk is mechanically stable, biocompatible, safe for the human body, with high surface-to-volume ratio, and low immunogenicity.
Unique medical and functional properties
The PrintyMed artificial spider silk is mechanically stable, biocompatible, safe for the human body, with high surface-to-volume ratio, low immunogenicity. It provides physical functionality only – our products have no pharmacological effect
PrintyMed scientists have developed a unique method for producing chemically modified artificial spider silk by bioconjugation. The method mimics the native process of spider silk formation and yields artificial fibers that reproduce to a large extent the properties of natural spider silk. A great advantage of the method is the possibility of tailoring the material properties and introducing new functionalities enabled by the chemical modification of designed spider silk proteins. Further research is being carried out to adapt the method to 3D printing technology.
Material advantages:
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Mechanically stable
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Biocompatible
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Safe for the human body
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High surface-to-volume ratio
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Low immunogenicity
Applications:
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Cosmetics
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Coatings for medical devices
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Drug delivery systems
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Tissue regeneration
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Bioprinting
Artificial spider silk for bioprinting
Spider silk is considered one of the most promising scaffolding materials as it is biocompatible, biodegradable, and has extraordinary mechanical propertiess.
Cells in human tissues reside in a solid matrix called the extracellular matrix (ECM), which can have a variable tissue-specific composition. The ECM provides structural support for cells to attach to and grow in three dimensions.
It also gives the tissues certain mechanical properties such as strength and elasticity that ensure their specific functions (e.g. stretching of muscles, skin resilience), and provides a degradable environment necessary for tissue remodeling (e.g. during wound healing). Because of the complexity of the ECM, in tissue engineering, it is replaced by different biomaterial scaffolds, which mimic the biological and mechanical functions of native ECM.
PrintyMed spider silk protein solution
3D printing
Scaffold
Addition of cells
Artificial organ
Potential use:
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Skin repair
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Bladder reconstruction
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Bone regeneration
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Cartilage regeneration
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Heart muscle regeneration
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Peripheral nerve regeneration
The Founders
Dedication. Expertise. Passion.
Jekaterina Romanova
Experienced serial entrepreneur, passionate about the healthcare.
For last 5 years has developed several deep-tech start-ups in medical field.
Actively involved in local entrepreneurship community as associate of the accelerator and investment fund, mentor, incubation program leader, lecturer.
Kristaps Jaudzems
Head of the laboratory at the Latvian Institute of Organic Synthesis.
For more than 10 years in spider silk research.
Got national award for one of the most significant achievements in Latvian science in 2021.
Sandra Treide
Medical expert, doctor.
Mor than 25 years of experience in the pharmaceutical business.
Expert in the commercialization of new medical technologies and medical devices.
Our Publications
(23.03.2022.) Engineered Spider Silk Proteins for Biomimetic Spinning of Fibers with Toughness Equal to Dragline Silks Tina Arndt, Gabriele Greco, Benjamin Schmuck, Jessica Bunz, Olga Shilkova, Juanita Francis, Nicola M Pugno, Kristaps Jaudzems, Andreas Barth, Jan Johansson, and Anna Rising* - Advanced Functional Materials; https://doi.org/10.1002/adfm.202200986
(07.04.2022.) The dimerization mechanism of the N-terminal domain of spider silk proteins is conserved despite extensive sequence divergence; Médoune Sarr1 , Kristine Kitoka2 , Kellie-Ann Walsh-White1 , Margit Kaldmäe3 , Rimants Metlans2 , Kaspar Tars4 , Alessandro Mantese5 , Dipen Shah5 , Michael Landreh3 , Anna Rising6,7 , Jan Johansson1,7, Kristaps Jaudzems2,*, and Nina Kronqvist1,7,*; Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology, https://doi.org/10.1016/j.jbc.2022.101913;
(14.06.2022.) Solution Structure of Tubuliform Spidroin N-Terminal Domain and Implications for pH Dependent Dimerization; Megija Šede, Jēkabs Fridmanis , Martins Otikovs 1 , Jan Johansson , Anna Rising , Nina Kronqvist and Kristaps Jaudzems*; Frontiers in Molecular Biosciences; https://doi.org/10.3389/fmolb.2022.936887;
(15.08.2022.) Spidroin N-terminal domain forms amyloid like fibril based hydrogels and provides a protein immobilization platform; Tina Arndt , Kristaps Jaudzems, Olga Shilkova , Juanita Francis, Mathias Johansson , Peter R. Laity, Cagla Sahin , Urmimala Chatterjee , Nina Kronqvist, Edgar Barajas-Ledesma, Rakesh Kumar , Gefei Chen , Roger Strömberg , Axel Abelein , Maud Langton , Michael Landreh , Andreas Barth, Chris Holland , Jan Johansson1 & Anna Rising ; https://doi.org/10.1038/s41467-022-32093-7
